Histamine intolerance is gaining recognition as more individuals experience its diverse symptoms, including migraines, digestive issues, and skin reactions. This condition arises when there is an imbalance between histamine levels and the body's ability to break it down, primarily due to impaired activity of the enzyme diamine oxidase (DAO). In this article, we’ll delve into the mechanisms behind histamine intolerance, differentiating it from related conditions like amine intolerance and mast cell activation disorders. Understanding the role of the gut microbiome, dietary choices, and DAO production is crucial for developing effective management strategies that go beyond restrictive diets. We will also explore how to optimise histamine metabolism and support gut health through dietary and lifestyle modifications, helping you regain control over your well-being.